PRODUCT MONOGRAPH. PR. Cathflo. ® alteplase, recombinant . cell line into which the cDNA for alteplase has been genetically inserted. Read all of this leaflet carefully before you What Actilyse Cathflo is and what it is used for. 2. Contents of the pack and other information. 1. Drug monographs for CATHFLO ACTIVASE provide an overview of the drug Keeping the vial of Sterile Water for Injection upright, insert the piercing pin of the .

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Although these effects have not been confirmed in published medical literature or during clinical studies, clinicians should consider using methylsulfonylmethane, MSM with caution in patients who are taking thrombolytic agents until data confirming the safety of this drug combination are available. Slight foaming upon reconstitution may occur; standing undisturbed for several minutes is sufficient to allow dissipation of any large bubbles.

Avoid vigorous suction during attempts to determine catheter occlusion to prevent damage to the vascular wall or collapse of soft-walled catheters. Submit the form below to share this with a friend or colleague.

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I can not find any information as I believe it is off label. Aliquots retain bioactivity for 6 months. Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term studies in animals have not been performed to evaluate the carcinogenic potential or the effect on fertility.

Moderate Danazol inxert decrease hepatic synthesis of procoagulant factors, increasing the possibility of bleeding when used concurrently with thrombolytic agents.

Genentech does inseert recommend and does not endorse the content on any third-party websites. The ACCP clinical guidelines do not recommend the use of thrombolytic therapy for the treatment of acute ischemic stroke in children. In exploratory, multivariate analyses, age more than 77 years was among baseline characteristics associated with an increased risk for intracranial hemorrhage. Because omega-3 fatty acids inhibit platelet aggregation, caution is advised when icosapent ethyl is used concurrently with anticoagulants, platelet inhibitors, or thrombolytic agents.


The safety and effectiveness of alteplase have not been established in adolescents, children, infants, or neonates for indications involving the treatment of systemic thromboembolic events e.

Such force could cause rupture of the catheter or expulsion of the clot into the circulation. Cathflo Activase should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Cathflo Activase (alteplase) dose, indications, adverse effects, interactions from

Major Due to the increased bleeding risk, avoid concurrent use of rivaroxaban with thrombolytic agents; the safety of concomitant use has not been studied. Moderate NSAIDs can cause GI bleeding, inhibit platelet aggregation, prolong bleeding time; these pharmacodynamic effects may be increased when administered packagr patients receiving thrombolytic agents.

Your email has been sent. If you have time, don’t bother checking after the first 30 minuets. However, based on the drug’s large molecular weight and short half-life, experts state that clinically significant amounts of drug pakage not expected to be found in breast milk. The use of alteplase for occluded central venous catheters has not been studied in patients known to be at risk for bleeding events that may be associated with use of thrombolytics.

Withdraw 2 mL into glass vials and cryopreserve at degrees C for 2 weeks; then, thaw and maintain at 22 to 24 degrees C for 24 hours; then, store at degrees C for up to 19 days. However, the use of 0. One episode of ecchymosis was reported, but no major bleeding episodes occurred. Patients should be closely monitored for signs and symptoms of bleeding when a thrombolytic agent is administered with vortioxetine and instructed to promptly report any bleeding events to the practitioner.


Children and Adolescents weighing 30 kg or more. Packae hope this was helpful to you. Patients should be closely monitored for signs and symptoms of bleeding when a thrombolytic agent is administered with trazodone. If the mg vial is used, the needle should be inserted away from the puncture mark made by the transfer device.

Various doses and administration times have been studied; the lowest effective dose has not been determined. Severe Based on the pharmacology of warfarin, other thrombolytic agents could cause additive risk of bleeding when given concurrently with warfarin.

We do not record any personal information entered above. I had an inservice earlier this year and learned a ton. Preparation of bolus dose: Bleeding The most frequent adverse reaction associated with all thrombolytics in all approved indications is bleeding.

Moderate Platelet aggregation may be impaired by vortioxetine due to platelet serotonin depletion, possibly increasing the risk of a bleeding complication e. Initiate therapy as soon as possible but within 3 hours of onset of stroke symptoms.